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Friday, July 24, 2020 | History

2 edition of effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on T cell activation found in the catalog.

effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on T cell activation

David M. Shepherd

effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on T cell activation

by David M. Shepherd

  • 293 Want to read
  • 26 Currently reading

Published .
Written in English

    Subjects:
  • Tetrachlorodibenzodioxin -- Toxicology.,
  • T cells.

  • Edition Notes

    Statementby David M. Shepherd.
    The Physical Object
    Pagination151 leaves, bound :
    Number of Pages151
    ID Numbers
    Open LibraryOL18138671M

    Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the proliferation and death of HepG2 cells are dependent on the concentrations of FBS in vitro. (A) Cells (1× cells/per well of ml in well plates) were cultured in α-MEM containing different concentrations (10, 1 or %) of FBS in the presence of either the vehicle (1% DMSO) or 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Class: Small Molecule: Description: 2,3,7,8-Tetrachlorodibenzo-p-dioxin is the most toxic of 75 chlorinated dibenzo-p-dioxin (CDD) congeners. CDDs are a class of manufactured chemicals that consist of dioxin skeletel structures with chlorine

      An in vivo model was used to examine the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on various parameters of T-cell-activation. In this model, the hamster anti-mouse monoclonal antibody C11 (anti-CD3) to the CD3 portion of the murine T-cell receptor was injected into both rear footpads of female C57B1/6 mice and the draining popliteal and inguinal lymph node cells (LNC) were Looking for online definition of 2,3,7,8-tetrachlorodibenzo-p-dioxin or what 2,3,7,8-tetrachlorodibenzo-p-dioxin stands for? 2,3,7,8-tetrachlorodibenzo-p-dioxin is listed in the World's largest and most authoritative dictionary database of abbreviations and acronyms "Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on cell growth and ,3,7,8-tetrachlorodibenzo-p-dioxin.

    Ma K 2,3f 7,8-TETRACHLORODIBENZO-p-DIOXIN Health Advisory Office of Drinking Water U.S. Environmental Protection Agency I. INTRODUCTION The Health Advisory (HA) Program, sponsored by the Office of Drinking Water (ODW), provides information on the health effects, analytical method- ology and treatment technology that would be useful in dealing with the ?Dockey=   The purpose of this study was to evaluate the effect of maternal exposure to the AhR-specific ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the development of rat pre-implantation embryos with respect to nuclear and cytoskeletal architecture and cell lineage ://


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Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on T cell activation by David M. Shepherd Download PDF EPUB FB2

Previous reports have indicated similarities in the actions of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the polyclonal B cell activator Staphylococcus aureus Cowan Strain I (SAC) on the in vitro T-dependent antibody response to :// The 2,3,7,8-tetrachlorodibenzo-p-dioxin is quantified by the isotope dilution technique with (13)C,3,7,8-tetrachlorodibenzo-p-dioxin as the internal standard.

The part per quadrillion limit of detection for g samples is more than adequate for determining 2,3,7,8-tetrachlorodibenzo-p-dioxin concentrations in human serum ://   1.

Introduction. The persistent environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is usually present in a complex mixture of dioxin-like compounds and causes a variety of toxic effects [].As TCDD accumulates mainly in the liver   This study examines the effects of AhR activation on hepatic transcriptome and metabolome rhythmicity in male C57BL/6 mice orally gavaged with 2,3,7,8-tetrachlorodibenzo-p-dioxin   In the present study, we investigated the effects of potential endogenous ligand indirubin on the aryl hydrocarbon receptor (AhR) signalling, with a focus on the AhR-dependent gene expression and cell cycle progression in rat liver progenitor cells, and compared them with the effects of a model toxic AhR ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant which elicits hepatotoxicity through activation of the aryl hydrocarbon receptor (AhR). Male C57BL/6 mice Natural killer (NK) cell activity increased fold (P less than ) and fold (P less than ) in the blood and spleen, respectively, after 28 days, and these effects persisted on day The increased NK-cell activity occurred concomitantly with a decreased proliferative response of spleen lymphocytes to the T-cell mitogen Helder T () Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on early life stages of the pike (Esox lucius L.), Science of The Total Environment, /(80),(), Online publication date: 1-Apr Effects of 2,3,7,8-tetrachlorodibenzo-p-Dioxin (TCDD) on Development of Anuran Amphibian Environ.

Toxicol. Chem. 16 (2), – [Google Scholar] Sakamoto, MK; Mima, S; Tanimura, T. A morphological study of liver lesions in Xenopus larvae exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with special reference to apoptosis of   Abstract.

Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD) is a common environmental pollutant causing public concern. Using a cell culture system derived from rat granulosa cells that provides unique advantages for studying the molecular mechanisms underlying the action of TCDD, the influences of TCDD on FSH receptor (FSH-R) induction were ://   The widespread environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent toxicant that causes significant neurotoxicity.

However, the biological events that participate in this process remain largely elusive. In the present study, we demonstrated that TCDD exposure triggered apparent premature senescence in rat pheochromocytoma (PC12) and human neuroblastoma SH ?id=/ Abstract.

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds cause a number of toxic responses including wasting syndrome, thymus atrophy and immunotoxicity, reproductive and developmental toxicity, dermal toxicity, hyperplasias, and if not all toxic effects of TCDD have been found to be mediated by the arylhydrocarbon receptor (AhR) to which TCDD binds   A wide variety of immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in experimental animals has been documented.

In contrast, the impact of dioxin on the human immune system remains controversial, although adverse health effects have been reported in humans after occupational or accidental exposure to dioxin. Recently, Neubert et al.

() found that a dose   The 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant toxicant that mediates carcinogenic effects associated with oxidative DNA hexaenoic acid (DHA) with antioxidant functions has many biochemical, cellular, and physiological functions for :// Objective: We investigated the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the development and function of the EPB.

Methods: Timed-pregnant C57BL/6J mice were gavaged with corn oil or TCDD (10 μg/kg body weight) on gestation day Embryos were harvested on embryonic day (E) 15, E16, E17, and postnatal day (PND) :// Studies on the cell treatment conditions to elicit lipolytic responses from 3T3‐L1 adipocytes to TCDD, 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin Wen Li Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, California Abstract.

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on local circulation and apoptosis in the midbrain were investigated in zebrafish (Danio rerio) embryos during early s were exposed to TCDD from 24 h post fertilization (hpf) until observation, in water maintained at °:// 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a prototypic halogenated aromatic hydrocarbon (HAH), is known as one of the most potent toxicants.

At least a part of its toxic effects appears to be derived from its ability to induce TNF-alpha production. However, the signaling pathway of TCDD that leads The importance of pharmacokinetics in determining the relative potency of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuran.

Signaling Events Downstream of AHR Activation That Contribute to Toxic Responses: The Functional Role of an AHR-Dependent Long Noncoding RNA (slincR) Using the Zebrafish Model,3,7,8-tetrachlorodibenzo-p-dioxin. The endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been demonstrated to disrupt hormone signalling, reduce fertility, interfere with embryo development and cause spontaneous miscarriage in humans.

The precise mechanisms of its effects on. Mima S, Sakamoto MK, Tanimura T. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on development in Xenopus laevis after continuous exposure from blastula to larval stage. Environ. Sci.

; – [Google Scholar]2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is known to induce neurotoxic effects. However, the mechanism of TCDD-mediated signaling pathways and its possible molecular targets in The use of this drug in zebrafish can lead to side effects unrelated to JNK inhibition due to its function as a partial agonist of 2, 3, 7, 8- TetraChloroDibenzo-p-Dioxin (Valesio et al., ).